A 10-Part Series on ISPOR’s Top HEOR Trends: #3 Artificial Intelligence

AI has jumped from #10 to #3 in ISPOR’s 2024–2025 HEOR Trends report. The report highlights the growing use of:

• Large Language Models (LLMs) to summarise clinical data and support documentation

• Machine Learning (ML) to analyse high-volume data, generate statistical code, and improve economic models

ISPOR’s Good Practices report outlines 5 key HEOR applications for ML:

• Cohort selection for more precise study populations

• Identifying predictors of health outcomes

• Predictive analytics for high-risk events

• Causal inference using methods like targeted maximum likelihood estimation

• Reducing uncertainty in economic model development

REAL-WORLD APPLICATION OF AI IN HEOR

AI is reshaping how HEOR teams generate, analyse, and communicate evidence. Here are some examples:

• AI-assisted Literature Reviews & SLRs

• Economic Model QA & Automation

• HTA Submission Support

• Real-World Evidence (RWE) Generation

• Value Communication Tools

• Protocol & Report Writing

WHAT THIS MEANS

AI is augmenting what HEOR teams can do. It enables teams to move faster, work smarter, and deliver more value-driven insights. What AI enables in HEOR:

• Faster evidence generation: AI tools reduce the time spent on literature reviews and data extraction

• Smarter modeling: Improve model structure, calibration, and documentation with ML and automation

• Enhanced scenario testing: Simulate price/access strategies quickly and iterate in real time

• Accelerated content development: Draft protocols, value narratives, and HTA summaries more efficiently

• Deeper insight from RWD: Use ML to identify trends, outliers, and patient subgroups in complex real-world datasets

WHAT WE DO

AI is already part of how we deliver faster, smarter results. We leverage AI to maximise efficiency and free up our team to focus on delivering strategic, high-value insights for our clients. From streamlining evidence reviews to simplifying complex workflows, AI helps us move faster.

Want to explore how AI could support your next HEOR project? Let’s talk.